1 2 3 4 5 6 7 8 9 10 11 12

6

Results

Depending on the duration of exposure, aluminium affected


AChE activity in the striatum brain region. The AChE activity


was significantly increased (p<0.001) after 4 and 14 days of

exposure (Fig. 1). After 60

days

of

aluminium

exposure,

the

enzyme

activity

compared

to

control

group

was

significantly

decreased (p<0.001). Increase in enzyme activity after 4 days of


exposure (110%) declined with increase in duration of exposure


to 14 days (61%) and 60 days (-67%).


DISCUSSION


Aluminium exposure producedbiphasic change in the AChE


activity in the striatum brain region. Studies have shown that


aluminium is able to produce biochemical changes in the brain at


shorter duration of exposure. Gulya et al., [7] have observed


increase in AChE activity in rats exposed to aluminium after 15


days. However, the increase in enzyme activity reported were not

statistically

significant.

The

results

of

the

present

study

reveal

a

significant

increase

in

AChE

activity

at

shorter

duration (4 and 14 days) of exposure. Earlier reports have shown

increase

in

AChE

activity

on

aluminium

exposure

in

dorsal

thoracic region [17], frontal cortex

[20]

of

rabbits

and

in