KUMAR2

Abstract: S.KUMAR AND S.L.MAHESWARI.Chronic Effect of Aluminium Exposure on

Rat Brain Acetylcholinesterase Activity and Lipid Peroxidation Level. The

neurotoxic effect of aluminium was studied in the brain regions of rat

repeatedly exposed for 450 days at a dose of 320 mg/kg body weight. The

marker enzyme of cholinergic neurons, acetylcholinesterase activity and

the marker of lipid peroxidation, malonaldehyde level were measured in

different

brain

regions.

There

and

were

regional

differences

brain

acetylcholinesterase

activity

aluminium

lipid

peroxidizability

among

region's

following

exposure.

Of

the

brain

regions

studied,

decrease in acetylcholinesterase activity were found to be high only in

olfactory lobe, striatum and cortex. Acetylcholinesterase activity

was

not significantly different from control animals in hippocampus and mid

brain regions. Lipid peroxidation level in the brain regions increased

and was near to control level in olfactory lobe, spinal cord and cortex.

Lipid

peroxidation

level

in

the

and

brain

there

regions

does

not

influence

acetylcholinesterase

activity

was

no

relation

between

the

values

obtained.

The

results

show

that

chronic

aluminium

exposure

produced

restricted

changes

on

the

parameters

studied

in

the

brain

regions and few brain regions were able to overcome the toxic effect of

aluminium.

KEY WORDS:

Lipid Peroxidation, Rat Brain Regions