the

is

aluminium

Increased bioavailability of

has

raised

the

concern

on

toxic

effect

of

aluminium.

The

cholinotoxic

effect

of

of

aluminium

already

well

established.

The

biological

response

an

organism

aluminium

following exposure to

a

chemical

may

be

biphasic.

Although

induced biphasic change has been reported in diverse organ systems, the

biphasic effect on cholinergic system has received less attention.

In

vitro and in vivo studies have shown aluminium induced biphasic effect on

the

marker

enzyme

of

cholinergic

system,

acetylcholinesterase.

The

biphasic effect of aluminium on the acetylcholinesterase enzyme activity

may be due to the direct neurotoxic effect of the metal and the level of

aluminium

accumulated.

Among

various

membrane

hypothesis,

peroxidation

induced

changes in the structure of

following

aluminium

accumulation

seems to explain the biphasic effect of aluminium on acetylcholinesterase

activity.